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In the present invention, tadalafil may be commercially available or synthesized by a method known in the art, but is not limited thereto. The tadalafil of the present invention can be used in various forms such as tadalafil free base or its pharmaceutically acceptable salts, isomers, racemates, hydrates and solvates, so long as equivalent pharmacological activity is maintained. The pharmaceutically acceptable salts include salts derived from pharmaceutically acceptable acids or bases. The pharmaceutically acceptable salts in the present invention mean any organic or inorganic addition salt which has a relatively nontoxic and innocuous effective action on the patient and in which side effects due to the salt do not impair the beneficial efficacy of the pharmacologically active ingredient do. Examples of pharmaceutically acceptable salts of tadalafil include hydrobromic acid salts, phosphates, sulfates, hydrochlorides, malates, fumarates, lactates, tartrates, citrates, besylates, camsylates and gluconates. Because tadalafil is substantially water-insoluble, its solubility improvement is essential for the preparation of oral solutions. The oral liquid preparation of the present invention is characterized by containing diethylene glycol monoethyl ether and a surfactant in order to substantially dissolve tadalafil in a solution to improve dissolution rate and bioavailability. Diethylene glycol monoethyl ether in the present invention can be used for commercial Gattefosse Vardenafil 20mg in UK. In the present invention, the surfactant is a substance that adsorbs on the interface and reduces its surface tension, and may be any one or more selected from the group consisting of a nonionic surfactant, a cationic surfactant, an anionic surfactant, and a positive Vardenafil 20mg in UK surfactant have. Preferably, the surfactant included in the oral solution of the present invention may be fatty acid glycerol ester, poloxamer, polyoxyethylene castor oil or the like, but is not limited thereto. The oral liquid preparation of the present invention is advantageous in that it has excellent physicochemical stability of tadalafil and is not easily recrystallized at low temperature or dilution. In addition, the oral liquid preparation of the present invention has a remarkably high solubility of tadalafil in a liquid agent due to the combination of diethylene glycol monoethyl ether and a surfactant, and has an effect of providing rapid drug efficacy and excellent bioavailability in accordance with fast dissolution. Preferably, the oral solution of the present invention contains tadalafil or a pharmaceutically acceptable salt thereof in an amount of 2 to 20 mg in the unit dosage form.



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